If in doubt, use the lower setting.
Most PC133 memory is CAS 2, but there's still a lot of CAS 3 memory about. CAS (Column Access Strobe) cycles must be manually and correctly set, or the PC will develop a tendency to hang. If you're lucky, the information will be on the DIMM module.
CAS has been explained in other postings on this forum, but what it refers to is how many times per cycle the RAM is checked, by looking up the contents as a column of data. A smaller number is more efficient.
This link explains it very well indeed;
As Minde_tech says, most PC100 and PC133 (and even some PC66) DIMMs will work happily alongside each other, but will drop to the lowest chip speed. On your board, the fastest they can run at will be 100Mhz (the speed of the FSB on your board).
If the DIMMs are non-branded, or the motherboard does not support using both types, there is more of a risk that they won't work together. In most cases they should do.
I hope this helps