I've used IBM sure POS at a few different clients, and though I found out some things IBM didn't know, they were pretty helpfull and had a pro in each city if I needed him. Touch screens, poll display and cash drawers intergrated makes the system look slick. It's all compacted into one basic model, but can wall mount it, put it all together, seperate or whatever the client wants. Their keyboard sucks though, too small and different. It only has option for intergration with a normal roll receipt printer, we were using an epson slip printer and though it fit in the hole, it was a different color. Comes with an intergrated MSR option and a different display option too instead of the traditional poll, it's back of the monitor, pretty slick.
All pretty nice and of course anything you get is going to work with POS software since it's installed over the OS.
Of course I had another client that just used Lap Tops with USB MSR's, printers and cash drawers.