Set up the device in Devices (Ip address etc as you would a workstation)
in Configurator set the font styles, menu board layouts etc.They are displayed as ASPX (xml ASP pages) running off the IIS of the server (much like Mgr Procedures, ReportViewer etc).
Key layouts are essentially column based. The IP address is for the Display controller for the display. Any Windows CE or Win32 device can be the controller.