Install Norton Antivirus for Exchange on the server, then go to the Symantec knowledge base and search on how to block file types. There are two associated documents you will need to read, but implementing the block is fairly easy (just be sure to follow the instructions carefully). Another option is to install a NAV Gateway. This will give you a much wider range of message blocking options. It's more complicated to set up, but may be worth the effort, depending on your needs.
I'm using McAfee GroupShield Exchange. All versions give you the ability to block files by extension, but the latest version allows you to block by subject line as well.
I've been quarantining all .exe, .pif, .scr, .com, etc. for the last three years, and we haven't suffered any email borne viruses since. Very solid product.
I'll back Eksistenz!! I too use Groupshield 5.0 and love it. Somewhat complicated to implement, but if you set it up right you'll have no problems! I block the same extentions as we have been virus free for quite some time.
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