We are having a very strange problem that I cannot replicate. A few users say that they will work on an Excel file, do work, save it, and when they re-open it, none of their work is saved. It doesn't matter if the file was saved to the desktop or a shared drive. Or cells are going blank or shifting up when they reopen. It is only with Excel files, and it is only a few users. I have tried running Virus Scans, used McAfee's Stinger to check for anything new, ran AdAware and Spybot. Went so far as to replace one user's machine, and she is starting to have the problem again. I am at wits end. The users can never replicate the problem with me sitting there, nor can I replicate the problem on my machine. Web searches have turned up nothing. Nobody else has ever heard of this problem. Thanks for any ideas. I will gladly share more info if anybody needs it. I am about to loose what hair I have left.