Pdox45 runs fine in XP, I had alot more problems with 2000 than I did with XP. As for installation it no different, Langley is right about the printing, but only if you share printers over the network, because pdox uses LPT port printing and port mapping is a little tricky in 2000 and XP but can be done. If you run pdox from nework drives, and after installation it seem to really drag when switching drives or directories, after a month of headaches, believe me, it's a network issue because of the higher security levels in the OS, it's not a comptibilty issue.
Brent