SQLSister,
Yeah, good idea. I have elimated any virus programs and such. Plus, my programmer has sworn to me that he's not running anything at those times. I've loged the IP's that were connected to it and didn't see any of his programs do it. We have managed to find some queries and joins that he has begun to "improve". (At least something good is coming from this.)
Also, there isn't anything running in the background on the clients. They are all operators taking calls. And these times of day are high traffic times, but we have handled this same amount of traffic, and more. Plus, this came on rather sudden.
Interesting enough though, two of the monitors that would indicate that this is cased by a CPU bottleneck, Processor Time and Processor Queue Length, are not spiking at these times. So, that's telling me that there is something that is using the CPU at the same times the operators are. But it looks like I need to find out exactly what that is, but how????