What are you using VSS with. I've had experience of setting up VFP6.0 and VSS and that took me ages to work out as there is no decent tutorials or help anywhere.
The first thing you do is set up a VSS database using the VSS Administrators Tool. (Tools, create database)
You can then add users to the VSS database again with the admin tool (Users, Add users).
Use Tools, Otions and select the "project security" tab to set security options.
Thats basically it for setting up the minimum. The hard part was finding out how to use it with the other product; in our case Visual Foxpro. If you're using Visual Foxpro then I may be able to help if not then the best of luck - it took me weeks to crack.