Others may be able to speak to this better, but I am under the understanding that VBScript can not access dll on your local machine for security reasons. (think what might be embedded into web sites if this were the case).
I think that's true, but what VBScript can do is access any ActiveX/COM objects that are registered on the server. It would seem that if you wanted to access the WinAPI, you'd have to write a COM DLL that contains an object that wraps calls to the WinAPI.
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