The "simple obvious solution" of scrambling the puzzle to create a solvable configuration is ok for some purposes, but is worse than a mathematical proof of impossibility for others.
Here is my understanding of what determines whether a configuration is solvable or not:
1. "Solve" the proposed configuration by transposing two tiles at at time, or a tile and the blank space, until you arrive at the solution. It's irrelevant for this purpose whether the transpositions are legal moves in the 15 puzzle. All you are interested in is getting from the starting position to the solution by a series of binary transpositions.
2. Note whether the number of transpositions in step 1 is an even or odd number.
3. Mentally color the puzzle grid in a white and black checkerboard pattern. Note whether the blank space has changed colors from the starting position to the solution.
4. Based on the previous steps, the following two situations are solvable:
A. The blank space has switched colors and the number of transpositions is odd.
B. The blank space remains on the same color and the number of transpositions is even.
As a simple example, consider figure 4 in the article cited by SamBones. You get from the starting position to the solution by swapping tiles 14 and 15 and the blank space remains in the same location (i.e. has not changed color) You have an odd number of transpositions and no change in color - that's not a solvable configuration.