You can't boot to safe mode, and windows is acting funny. If you've eliminated the possiblity of virus/spyware, I'd just format and reinstall. Something may have gone wrong. After you reload the os, make sure windows operates ok. As you reinstall programs, do so one at a time, and reboot. Then test windows and make sure its okay. If you make a change and see a problem, then at least you'll know what the problem is. If you format and reload and have problems out of the gate, then you might have a hardware problem.
Matt J.