SendKeys keystrokes go to whatever window is active when the command is issued. If your Access window is active (probably true), it doesn't have any command that's initiated by Ctrl-Esc, so it just ignores the keystrokes.
To get this to work, you'd have to activate the TaskBar window, I think. (Although it doesn't look like what you usually think of as a window, it is one; everything on the Windows screen is a window, or part of a window.) Unfortunately, I don't know how you'd do this. It would probably involve a Windows API call, though.
Note: SendKeys is considered a "quick and dirty" way of controlling the Windows environment. Because it's hard to detect or control which window is active at the time you issue the SendKeys command, you can get different results at different times or on different machines. It would be better if you could find an alternate way of doing whatever it is you're doing with SendKeys. Why don't you describe what you need, and maybe we can suggest a safer way of doing it? Rick Sprague