Gotcha -- When I saw the " and the (In) I thought you were referring to the sql quotes and the IN Predicate -- it's friday and early
Which DB are you using? I am sure there are some functions for your DB that could make this quicker, but here is a generic way in CF that you could do it:
Query the database and do a select of the records, loop through that -- check to see if the field(s) have a quote symbol and relace it with in, and do an update.
e.g
<cfquery name="foo" datasource="bar">
Select recordID, field1, field2 from myTable
</cfquery>
<cfloop query="foo">
<cfif find('"',field1) neq 0>
<!--- I set the record ID to a temp var, because I have run into problems using a query variable inside another query when it is in a loop, setting it to a temp variable gets around this.
--->
<cfset tmpID = recordID>
<cfset NewField1 = Replace(field1,'"',"in","all"

>
<cfquery name="foo1" datasource="bar">
Update myTable
Set field1 = '#NewField1#'
where field1 = tmpID
</cfquery>
</cfif>
<!--- Now do the same for field2 --->
<cfif find('"',field2) neq 0>
<cfset tmpID = recordID>
<cfset NewField2 = Replace(field2,'"',"in","all"

>
<cfquery name="foo1" datasource="bar">
Update myTable
Set field1 = '#NewField2#'
where field1 = tmpID
</cfquery>
</cfif>
</cfloop>