Well, the first question is "what other programming languages have you worked with?". Let's start where you are most familiar, and find the scripting language that resembles it the most.
For example, if you have worked with C-oriented languages before, such as C++, Java, PHP, even Javascript, then Perl will probably have a more familiar syntax than the others. This is where I came from, and I am sticking with Perl, since I realized it can do just about anything you would ever want in a Unix system. For really simple stuff, I occasionally use Bash.