Maybe you didn't understand Jeff's reply... Unfortunately, I cannot say the word "No" in any less syllables than he did ;o(
AFAIK, you cannot launch (or lunch, for that matter) standalone applications (i.e. EXEcutable files) using a web browser in either full-screen mode, or a window, while still keeping it cross-browser or cross-platform.
You might possibly be able to use an ActiveX control to do the job in IE only, but you'd need to do more research on this (not sure if the FileSystemObject allows execution, and unsure about the WSH methods availble).
Hope this helps,
Dan