The usual basic size to develop for used to be 800x600 pixels. I think now its accepted to be 1024x768.
Still if you make a website that is basically 800 x 600 you can avoid scrolling for anybody above that resolution.
A fluid design as traingamer pointed out, will take anything above or below your basic resolution and expand or contract to accommodate. Although sometimes contracting can have unpredictable results, because everything might get scrunched up.
Usually a fluid design with a minimum aspect of 800x600 pixels should work for almost all users, and browsers.
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Ignorance is not necessarily Bliss, case in point:
Unknown has caused an Unknown Error on Unknown and must be shutdown to prevent damage to Unknown.
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