I use it for my network with no issues. Have it running with Norton Corp Edition 9 and PP version 5 / the latest from CA.
Makes it a lot easier with central management over the others. Was also looking at another spyware remover called Web Root Spy Sweeper Enterprise that had central administration, but i ended up going with PP no particular reason.
On the main server that PP runs on i also run Ad-Aware SE, Spybot Search and Destroy 1.3, Spyware Blaster, and have no conflicts among them.