Depends on whether you have used any transparency effects (drop shadows, feathering, gradients etc) and who is going to print the PDF. If it is going to a printer you know has the latest equipment (esp the RIP) then any transparency effects will print correctly. However, if you don't know who will be printing it, nor the state of their equipment, then PDF/X-1a is the safest, as it flattens any transparency prior to RIPping. Any problems can be seen when viewing the resultant PDF before it goes to the printer.