Have you ran disk defragmenter lately?
Anyway, Openme.exe is an XXX dialer which can create a very big phone bill. You can remove it using Ad-aware which is free or do it manually.
Here's manual directions. Just do what you haven't already done. #4 will get rid of the startup error.
1. Go into add/remove programs in the control panel and look for something called WebDialer and uninstall it if it's there. It may or may not be there.
2. Press ctrl + alt + del and 'end task' on openme.exe. Also see if there's something there that looks like 5-2-46-112.exe. If so end task on that too. The numbers may be slightly different but will be similiar if there.
3. Then click start--find--files--and search for openme.exe. When found delete it. Then search for the other file I mentioned if it was listed when you did a ctrl + alt + del and delete that too.
4. Click start--run--type system.ini or sysedit and click ok. In system.ini look for this line near the top:
shell=Explorer.exe openme.exe
Delete
ONLY the openme.exe part so that it just says
shell=Explorer.exe with nothing typed to the right of it. (Be careful deleting so that you don't start deleting the system.drv line underneath.) Then close system.ini and click yes when prompted to save changes. Then restart and see if the problem is gone.
After restarting go into the Temp folder at c:\windows\temp and delete everything in it. The dialer may have placed some files in there.