Yes, but that's not using the directory feature of One-x Communicator. It's just using display features.
The directory feature that you use to look up contacts in One-x really only integrates with Outlook, Active Directory, and Lotus Notes email. If you integrate with both AD, and say, Outlook, it will search both to find a contact for you.
Using the Directory button is really just remote control of a phone feature. While that works, it's not really One-x integrated with a searchable database.
Carpe dialem! (Seize the line!)