I've similar problem with different platforms:
Server
W2K SP3
NetWorker 6.1.1 build 238
Client
W2K SP3
NetWorker 6.1.1 BSM Lotus 2.1.0-001
Lotus Domino r Server (Release 5.0.11 for Windows/32)
12/06/02 01:01:39 PM savegrp: atsitfi15npge:NOTES: started
nsrnote.bat -s sbkitfi01npge -g bck_lotus -LL -m atsitfi15npge -l full -W 78 -N NOTES: NOTES:
12/06/02 01:01:39 PM savegrp: atsitfi15npge:C:\ started
save -s sbkitfi01npge -g bck_lotus -LL -f - -m atsitfi15npge -t 1039175674 -l incr -W 78 -N C:\ C:12/06/02 01:02:04 PM savegrp: atsitfi15npge:NOTES: succeeded.
atsitfi15npge:NOTES:: No full backups of this save set were found in the media database; performing a full backup
* atsitfi15npge:NOTES: rcmd atsitfi15npge, user root: `nsrnote.bat -s sbkitfi01npge -g bck_lotus -LL -m atsitfi15npge -l full -W 78 -N NOTES
: NOTES:'
* atsitfi15npge:NOTES: nsrnotesv: addEntry: C:\WINNT\lotus.ini
* atsitfi15npge:NOTES: nsrnotesv: getR5NotesIni
* atsitfi15npge:NOTES: nsrnotesv: searchNotesSystem
* atsitfi15npge:NOTES: nsrnotesv: searchRestOfSys
* atsitfi15npge:NOTES: nsrnotesv: DTAW: Drive: C:* atsitfi15npge:NOTES: nsrnotesv: DTAW: Drive: D:* atsitfi15npge:NOTES: nsrnotesv: searchRestOfSys Fixed drives: 2
* atsitfi15npge:NOTES: nsrnotesv: pid: 3732 is parent
* atsitfi15npge:NOTES: nsrnotesv: Notes_ExecDirectory = C:\Lotus\Domino
* atsitfi15npge:NOTES: nsrnotesv: varp: creating a new varp, count is 6
* atsitfi15npge:NOTES: nsrnotesv: port = 17610, res = 0, errno = 22
* atsitfi15npge:NOTES: nsrnotesv: port = 17611, res = 0, errno = 148
* atsitfi15npge:NOTES: nsrnotesv: port = 17612, res = 0, errno = 0
* atsitfi15npge:NOTES: nsrnotesv: lgto_auth for `nsrd' succeeded
* atsitfi15npge:NOTES: nsrnotesv: port = 17613, res = 0, errno = 22
* atsitfi15npge:NOTES: nsrnotesv: port = 17614, res = 0, errno = 0
* atsitfi15npge:NOTES: nsrnotesv: lgto_auth for `nsrd' succeeded
* atsitfi15npge:NOTES: nsrnotesv: main: numSS 2 numBItem 529
* atsitfi15npge:NOTES: nsrnotesv: Notes Library initialization failed, error = 421
* atsitfi15npge:NOTES: nsrnotesv: Exit code: 421
12/06/02 01:02:04 PM savegrp: atsitfi15npge:NOTES: will retry 3 more time(s)
Any idea ?