I would take the new job, without looking back. It may not be in an area you are familiar with and would require you to learn something new, but as you noted, learning new skills is ever changing, too.
I have thought the way you are thinking, too. I have wanted to get out of IT for the last couple of years (been in IT for 11 years) but I stay because it is familiar. I have thought I would like to research or analysis positions which wouldn't be a stretch considering IT work. I also enjoyed stats in college and I enjoyed research in grad school.
My thoughts have been to take a couple of college classes to refresh myself in research/stats and then look for a job as a market researcher/analyst, which is a growing field.
In my previous job, I joked with a colleague about becoming a stats analyst like him. He said to come on over because they couldn't hire enough. It was for a gov't healthcare company, too, so they are not going anywhere. The pay is good and comparable to IT and they work 8-5 without a pager!