Thanks for the pointers guys, I wasn't aware of the imlplications that could arise at the RIP.
"Never use LZW compression if you are sending out for printing. Most printers do not want compressed file, it messes up the RIP, and slows down the processing of files."
Just to confirm, you are refering to TIF's, even when they are placed within a page layout program, such as Quark od Indesign?