Without linking your DLL to the MFC runtimes, no you won't be able to use any of the MFC classes (such as CObject, etc). The MFC libraries are an annoying overhead, both in terms of performance and size (especially when you have to ship them with a relatively small application) but I think the advantage of having such an extensive framework of pre-written Windows classes far outweighs this.
(Although I'm sure Win32 purists will disagree)