LOL - Anne, those I'd bring round personally
Leo, it's unlikely to be the *.xlb then as the problem was all but eradicated in XP and 2003. I would also have tended towards clearing out the temp files etc.
If the workbook had been corrupted you could have tried using the Open and Repair option, but if as you say others can open it OK, then that is unlikely to help either. I'm assuming that no other files are open at the same time, all other apps closed down etc and he still has this issue. Any chance he doesn't have as much RAM as the others, or are the hardware profiles identical too.
You could also try the following KB
814112
Files on Network Shares Open Slowly or Read-Only or You Receive an Error
or try the rest of the advice on Chip Pearson's site:-
In particular the Detect and Repair option for Excel
Regards
Ken..................
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