Not recommended. ISA Server has too many connections/possibilities to get infected potentially and you probably DO NOT WANT ePO to be the source of infections
Suggest a separate server for ePO, and if you can spare it, a separate SQL Server connected directly to the ePO server via cross-cable. This will ensure that the connections between the ePO server and the database is always on and quick.
HTH,
AVChap
... WARNING: The Surgeon General says to take my advise at your own risk.
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