In what particular scenario - a web based document? AFAIK it is not possible in this scenario as a local copy of the document is cached on the user's machine. I believe it is possible to keep the form data server-side, so that the client-side pdf does not actually contain anything when opened from the cache, but this is not an area I'm familiar with I'm afraid.
"If toast always lands butter-side down, and cats always land on their feet, what happens if you strap toast on the back of a cat and drop it?"
- Steven Wright