HERE'S WHAT WORKED FOR ME AFTER TRYING THE SOLUTION RECOMMENDED ABOVE AND STILL HAVING PROBLEM...Scenario first:
I have a WD 60 gig HD that was origially set as a Secondary Master WIN2000 NTFS D: drive. I ran format on it via WIN2000 "Computer Management" tools. I then removed the old C: drive and placed the WD 60 gig drive in the Primary Master position (all cables and pins[set as single] are set correctly) w/o the old C: connected.
I ran the WIN2000 install and it appeared to proceed correctly. But now on boot up I get the error, "Couldn't open the boot partition to check for signiture".
Trying to use the Data Lifeguard Tools insatll I get, "Invalid Drive Selection". It see it, will run diagnostics on it, but will not install/reinstall it.
In the computer BIOS it is not recognized either. BUT, when I put the original C: drive back in palce, the BIOS see's it.
I also tried the "Load setup defaults" and "Load BIOS defaults" and tried auto detect HDD...nothing.
>>>SOLUTION<<< = A BIOS UPGRADE and clearing CMOS. The BIOS that was on the system (ASUS P2B-F BIOS Revision 1009.B) "does not" support the 60 GIG drive.