This release has been a headache for us all around, if anyone is seeing problems with Web Manager saying that it may not have started completely, check Monitor > Blacklisted IPs and make sure that it hasn't blocked itself. If it has, add the IPO IP to the whitelist at System > VoIP, it should start working again.
We also saw issues with VMPro not starting as root and getting the correct permissions, as well as port 25 being closed and Resiliency not working.
Apparently SP2 is coming in the next few weeks...