Yes, go into the system with security officer permissions. Go into Communications, specifically TCP/IP Administration and enter the routes, for example:
190.123.xxx.0 this is the remote site ip address, the next entry should be your Cisco Router, let's say 190.123.xxx.1, finally you would have your netmask, example 255.255.255.0.
In your Cisco Router you would have your serial interfaces set up for each route. Then in the routing table of the router you would 190.123.xxx.0 255.255.255.0 serial o/1 for example. There should be an entry for every site you are attempting to communicate with, each entry would point to a different serial interface. If you have ten remote sites the routing table would have ten entrys ser 0/1, ser 0/2, etc. What is the specific router that you are using?