It may be that it is a start-up command to disable that part of the controls. If so, you can by pass these commands by holding down the F11 key when you open the file.
If this doesn't by pass it, go to the file in it's folder, highlight it, hold down Shift, then press Enter.
You should be able to go into start-up and re-enable it now.
Good luck,
Yarbz