What do you mean by "save changes"? You can't write to disk using javascript (if that's what you are hoping)... regardless of whether you attempt to use xpaths or not!
Javascript does not natively support xpaths - but there are several projects out there that attempt to do this.
XPath is primarily a way to locate elements, and AFAIK, has not a lot to do with saving files. So the answer is probably 'no', although as Jeff suggests, a quick Google search would confirm this.
Hope this helps,
Dan
Coedit Limited - Delivering standards compliant, accessible web solutions
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