hi blitz,
firstly no you cannot do these things in safe mode im affraid you have to do them from the bios (small memory with the hardware configs situated on the main board)
it would probably help you if you have the main board manula (if you built the system yourself you will certainly have it, if not you may not)
if you have, then it will clearly show you where the headers are for the cmos, usually 2 (sometime more) pins (usually open). all you do if close them for 30 seconds or so then remove the jumper and your done.
ok if you dont have your mainboard manual, i would suggest you go to the mainboard manufacturers site and downlaod the manual from there. (f you dont know what it is, either run some 3rd party software such as Sisoft sandra 2007 which is free to use, or simply take the side panel off your case and look at the board.
if all else fails, take the side panel off the case (with power off and static free hands) and look closely around the board you should somewhere see a smallish round battery, and very likely close to it, 2 small metal pins sticking up (it may even say clr cmos under the pins)
get yourelf a jumper socket or small screwdriver and carefully short the 2 pins together for about 30 secs.
reboot and imediatley press delete for a couple of seconds, you will then enter the bios of your mainboard.
using the arrow keys, enter and escape to go back, you can anvigate around the bios.
you should see a section that says load failsafe defaults, press enter, and then Y for yes.
go to save and exit bios, press Y again and your system will reboot.
if that doesnt workm boot into safe mode and remove your graphics drivers ( i had an identical problem and it turned out to be my graphics card at fault) after uninstalling them, reboot again
go to the website and download the latest drivers, and install them, reboot and see what happens.
good luck