Assuming everything is setup correctly (DNS is correct, DHCP doing the right 'stuff' for each subnet, and there are routes between networks if you have more than one Subnet/network), then yes.
Browse/connect a drive to the Server from the Home machine, and you should be prompted for the Server credentials - if the 2008 server is a DC, then provide domain user details ([domainname]\[username], then password), if its just in a workgroup, then enter the credentials of a user that exists locally on the server ([servername]\[username] and password).
Should work a treat!
Thanks, Mark