...many, like cartoon comics, will likely use illustrator for sharp scalable graphics, and probably scan in hand drawn versions beforehand...
...this could then be colorized in either photoshop or illustrator...
...if using a pixel based program, then resolution needs to be taken into account, suitable for high end print work, typically 300dpi at actual 100% size...
...for animating, flash or toonboom are used, some even go as far as to use 3d software like 3d studio max, maya or cinema 4d, in combination with Adobe After Effects or Apple's Final Cut Pro...
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