In Vista Ultimate there is a little Checkbox at the bottom of the Welcome Center Window which says 'Run at Startup (Welcome Center can be found in Control Panel, System and Maintenance)'. Unchecking the box does it for me; however I think some lesser versions of Vista do not have the checkbox. Personally I have not been able to find a switch in Control Panel as advertised/ suggested.
Googling for 'disable Welcome Center' turns up a registry hack. Be sure to create a restore point before you go there.
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