(Note: the good advice below has a bias in presentation)
This can be your mantra: Microsoft equals Viruses; No Microsoft product, No viruses
You can use the Firefox browser and the Thunderbird mail client (sadly to get Windows updates, you need to keep IE, but you can delete Outlook entirely)
Any office product that are not by MS reduce your Macro Virus risks
If you take the big step of a non MS OS, that wipes out 99.9% of the available viruses.
Meanwhile, I reccommend Adaware SE, Spybot search and destroy, hijackthis, stinger, and use of what ever web site filters your ISP offers
I tried to remain child-like, all I acheived was childish.