Yes
I wrote a FAQ on this that is posted to this site (how to properly configure DNS for Domain controllers I think its called)
Here's the run down:
1. PDCe - points to itself and itself only
2. Replica DCs (in same site as PDCe) - point to PDCe for preferred and themselves as alternate (use IP and NOT 127.0.0.1)
3. Replica DCs (in different site than PDCe) - first DC alphabetically in branch site points to PDCe for preferred and itself as alternate, other DCs in branch site point to first alphabetical DC in their site for preferred DNS and themselves as alternates
This will help you in troubleshooting DNS problems in the future, as well as help constrain replication, along with eliminating alot of nuisances that can appear and disappear in an hour
Desigining DNS like this was a requirement foer windows 2000. In windows 2003, they technically changed the way the lookup algorithm works, allowing DCs to point to themselves as preferred, technically, however, in practice, this is a bad idea to do either way. DCs are way more prone to not come up due to service race issues, and any other number.
For the best health you can get really (as far as DCs, AD, and DNS go), use the method I supplied you above.
Now as another thing it could be...
If you're DCs are multihomed (more than 1 NIC ENABLED; not counting teamed NICs), then that needs to stop as it too could cause this...disable unnecessary NICs, ensure adapter binding order is correct, move microsoft networks to top of bindings list (over MS terminal services), ensure no other protocols other than tcp/ip are installed, ensure advanced tcp/ip properties dns tab is at all defaults (append primary and connection specific DNS suffixes; append parent suffixes; register this connections addresses in DNS....everything else should be blank except for the DNS server IPs)
also ensure you don't have a disjointed name (check my computer properties on c omputer name tab...ensure full computer name is in the format of server.domain.com).
-Brandon Wilson
MCSE:Security00/03
MCSA:Messaging00
MCSA:Security03
A+