My words of wisdom, don't do it for any users if the will roam between NT4 and W2K or WXP, that is a big PITA and you will hate your self for a long, long time to come.
W2K, WXP, and W2K3 play fairly well together with some occasional annoyances, especially if you have a mix of differenct versions of office.
Training end users not to store data on their desktop has been challenging at times, do end users ever learn?
When you are roaming striclty within a common desktop image across an entire orginization it works like a dream.