We use McAfee VirusScan on servers/desktops, it's pretty good and it comes with a decent management console (ePO) for managing it in an enterprise. VirusScan includes a basic firewall and anti-spyware but we just turn this off through ePO policy, you can also buy the proper McAfee anti-spyware module that can be managed from the ePO.
Key thing if you're serious about AV though is run different AV products on you email servers/gateways than you do on your servers/desktops. No single product catches 100% of stuff, the more you have the more likely you are to detect them.
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