First of all I'd make sure the Option 61 is doing a daily backup and that you keep copy or two for storage reasons.
Also I'd power down the system by turning off the breakers at the bottom of each tower and NOT for each IPE shelf.
The reason for this is that there is a goo chance that the power unit switch will become faulty if you turn it off there. It's because the inside of the switch components can fail and recently I had a site where the system was working fine for years and as soon as we turned the IPE power unit off, it wouldn't work anymore.
Anyway, power it all down and make sure you don't suddenly turn it back on again as this is where most problems start.
If you have applications such as Call Pilot, Symposium, Sig Servers, Mmedia cards (IP devices) etc, then it's likely that they will all have to be rebooted again after the Meridian has been rebooted.
This is only my recomendation and I'm sure that other members will have other useful tips to give you.
All the best
Firebird Scrambler
Meridian 1 / Succession and BCM / Norstar Programmer in the UK
If it's working, then leave it alone!.