I'm trying to set up our exchange server to send out email. According to our ISP our settings for IMS are correct but all email sent to exchange gets stuck in the queue with destination host unreachable. Is there any special ports that should be opened besides 25&110? BTW, i'm using NT 4 (SP6) Exchange 5.5. Also the exchange server and microsoft porxy server reside on the same machine. Can this be a problem?