It depends on the workload the machine has and how you want to prioritize the processing. If the machine is lightly loaded, then you probably won't notice much of a difference. If your machine is pegged at 100% and you want your "Seti @ Home" processing to give up some priority, then [tt]nice[/tt] can make it run at a lower priority.
I've also noticed that the priority a process runs at because of a [tt]nice[/tt] command only seems to be a "suggestion" at best. You can't always speed up a process that's running slow, or slow down one that's eating up the machine.
Bottom line is, go ahead and use it, but your mileage may vary.
Hope this helps.