We're talking less than 100 mailboxes in the message store so I don't think we need a finely tuned structure other than separating out the log files."
There's a acronym that I like to use when it comes to SAN design that has been very successful for me - KISS. Keep It Simple, Stupid. In addition to that, Occam's Razor offers another great piece of advice - "All other things being equal, the simplest solution is the best." These two bits of wisdom have served me well in my years working on SAN/Storage/Unix/Veritas.
I offer those two items due to my opinion that everyone is making this far too complicated than it needs to be. There is great advice being given, but for your particular case I think simplicity is the best advice. You are working on only 100 mailboxes and the storage array has only 12 spindles. So performance shouldn't be the primary concern. In a 10,000 mailbox environment, performance followed by fault tolerance are the primary concerns. In any discussion about performance, RAID 6 should never be considered. It is by far the slowest performing RAID configuration due to the double hit of dual parity. In 99% of environments, a medium to large RAID 5 set will be more than sufficient.
I've used RAID 5 exclusively through Exchange, SQL, Oracle, File Servers, and Imagery Systems with little to no issues because the overall LUN design and system configurations were done correctly up front. These environments have been on both small and large arrays, from a NetApp FAS3020c to a Clariion CX500/700 to an HDS USP.
The biggest concern to worry about with Exchange and SQL is where the data and logs live. Logs should live on separate LUN's and more importantly on different RAID groups. With only 12 spindles, you could do something like a 4+1 and 5+1 RAID 5 sets with a single spare. Put your logs in the 5+1 and data in the 4+1 (assuming the groups have the appropriate amount of space).
There are many more concerns with getting into the SAN/Storage realm (array makes/models, switches, HBA's, drive types/speeds, system OS', fan in/fan out, queue depth, etc) than just RAID type. But without knowing more about what you're trying to do and with what sytems, I can only talk high-level.
Hope this helps.
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"Only two things are infinite, the universe and human stupidity, and I'm not sure about the former."
Albert Einstein