1) you might short out circuits by mounting Mobo to case. Not good, but not certain.
2) experiencing similar issue with home built system..there can be a number of causes for the system not to start, as I am learning.
---Bad PSU (happens. Just got off the phone with Antec tech support, and we think/hope this is the case.)
---Motherboard issues: Blown board? Incorrectly attached power swithc? Apparently, unlike older systems, newer PSU's are completely controlled through the Motherboard.
My solution tonight will be removing everything but the fans, repositioning the power switch, and trying it with the current fan and another one. Tech support suggests just cross connecting the PSU from another unit to determine whether it is a board/PSU issue.
No matter how you cut this, it will cost me money. How sad.