Yes,
We are currently using Legato 6.0.1 to backup Windows 2000. We have had problems backing it up from the server. The clients backups worked fine, but the server side wouldn't kick off. We found that in addition to putting the server in the server's file, we also had to add it in Win2K's hostfile. Of course the clients we have that are using DNS do not have this problem. The biggest surprise with the Win2K install is when you install from CD, it will automatically bring up a webpage. Don't install from the webpage. Kill it and install out of the explorer. I hope this helps.