Jpeg is lossy, so you have to save the master if you don't
want to kick yourself later. I sometimes do dozens of image corrections on one jpeg , and use the lowest compression option on save which seems to average out as about 7:1 over bmp, and it's very rare to find a degradation that I really care about. If you're really fussy, go back to the master and do them again, all combined, or combine a bunch when you start out. If you want to send them out, you can compress way down to save bandwidth, and if the receiver wants quality, send a moderately compressed version. I frequently compare bmp with jpeg on "problem" images and like jpeg.