Exchange 5.5 doesn't have the facility by default. However, a good number of mailserver anti-virus packages include an option to attach a disclaimer to any outgoing (Internet) emails.
We use Sybari Antigen which is easy to configure for both virus detection and adding a disclaimer.
I know you said without modifying the registry, but it's pretty easy and hassle free (assuming these are the reasons you wanted to avoid the registry):
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