I almost have this but not yet. Need some help from teh experst.

All five drop downs must also be false also. and I also need to check whether or not the selected index is > 0 first because you can have duplicate nonselected dropdowns.
Only the teams selected can be duplicates but I can have duplicate Null values.
This is what I have so far..
Dim flag As Boolean = False
''''''''''validate if the same two teams are picked
If ddlPick1.SelectedItem.Value = ddlPick2.SelectedItem.Value Then
'First& second are equal
If ddlPick2.SelectedItem.Value = ddlPick3.SelectedItem.Value Then
' first,second,third are equal
If ddlPick3.SelectedItem.Value = ddlPick4.SelectedItem.Value Then
' first,second,third,forth are equal
If ddlPick4.SelectedItem.Value = ddlPick5.SelectedItem.Value Then
' first,second,third,forth,fifth are equal
flag = True
End If
End If
End If
End If
If (flag) = False Then
'give error message
lblSubmitError.Text = "You have duplicate picks. Please pick again."
Exit Sub
End If