Some things to think about when making changes of this sort. First, how are you going to ensure the changes do not adversely affect anything else. Make sure you have a test plan and follow it. Make the changes to Development first before going to QA and Production. If you do not have a tool set up to compare the different versions of the database, you will have to keep track of exactly what you changed in order to ensure the same changes happen in all places. It is best to make the changes in the development database, script the changed objects and then apply the scripts to the other databases. This will help ensure consistency rather than using Enterprise manager in all three and maybe naming a new field test1 in one database and tets1 in another thus breaking any stored procedures dependent on the the new field being called test1.
Changes to tables after a database is in production can cause new bugs to creep in. You need to know exactly what objects you will be affecting by these changes, not only in the database, but in the user interface as well. For instance when I change a datatype, the XML that we use to call the stored procedure needs to change in the .NET interface and stored procedures that use table variables or temp tables may also need to change in order for them to still work. Triggers are a particularly difficult area when you make these changes, not only triggers on the tables changed, but triggers on other tables may be updating records in that table and may need to change as well. And you may also need to refresh or adjust any views based on these tables.
Since you are new to SQL Server, you are probably not very familiar with these databases. Before you go about making these changes, I would suggest you spend at least a day familiarizing yourself with the database tables, triggers stored procedures, user defined functions,relationship diagrams and user interface. This will give you a better understanding of the whole project and how much could potentially be affected by your changes. I would also suggest getting familiar with basic T-SQL syntax and how to use Enterprise Manager and Query Analyzer. A few days spent learning and understanding the basic design of your database will save you days maybe even months of debugging later. I highly recommend it.